Regulation and Compartmentalization of three protein kinase systems
نویسندگان
چکیده
منابع مشابه
Regulation of protein compartmentalization expands the diversity of protein function.
Proteins destined for the secretory pathway are translocated into the endoplasmic reticulum (ER) by signal sequences that vary widely in their functional properties. We have investigated whether differences in signal sequence function have been exploited for cellular benefit. A cytosolic form of the ER chaperone calreticulin was found to arise by an aborted translocation mechanism dependent on ...
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We have used a permeabilized cell assay and a synthetic peptide substrate (KRTLRR) to specifically monitor the activity of protein kinase C in PC12 cells preincubated with nerve growth factor (NGF), epidermal growth factor (EGF), or phorbol esters. Pretreatment of PC12 cells with 1 PM 12-0-tetradecanoylphorbo1 13-acetate or 1 I.~M phorbol dibutyrate stimulated the rate of KRTLRR peptide phospho...
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چکیده ندارد.
15 صفحه اولRegulation and compartmentalization of β‐lactam biosynthesis
Penicillins and cephalosporins are β-lactam antibiotics widely used in human medicine. The biosynthesis of these compounds starts by the condensation of the amino acids L-α-aminoadipic acid, L-cysteine and L-valine to form the tripeptide δ-L-α-aminoadipyl-l-cysteinyl-D-valine catalysed by the non-ribosomal peptide 'ACV synthetase'. Subsequently, this tripeptide is cyclized to isopenicillin N th...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1979
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.19.27